ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance
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چکیده
منابع مشابه
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy. ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting i...
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Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found commonly associated with the mitochondrion. L. major mutants lacking ATG5 (Δatg5) were viable as pr...
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Parkinson's disease (PD), a complex neurodegenerative disorder, is pathologically characterized by the formation of Lewy bodies and loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial dysfunction is considered to be one of the most important causative mechanisms. In addition, dysfunction of chaperone-mediated autophagy (CMA), one of the lysosomal proteolytic ...
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AUTOPHAGY-RELATED PROTEIN (ATG) 8-FAMILY INTERACTING MOTIF IN ATG3 MEDIATES THE ATG3-ATG8 INTERACTION AND IS CRUCIAL FOR THE CYTOPLASM-TO-VACUOLE TARGETING PATHWAY* Masaya Yamaguchi, Nobuo N. Noda, Hitoshi Nakatogawa§, Hiroyuki Kumeta, Yoshinori Ohsumi, and Fuyuhiko Inagaki Department of Structural Biology, Graduate school of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Integ...
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UNLABELLED Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung cancers, suggesting that autophagy inhibition may have antitumor activity. To assess the functional significance of autophagy in both normal and tumor tissue, we conditionally deleted the essential autophagy gene...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2016
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2016.1212786